替米沙坦对原发性高血压患者胰岛素敏感性的影响列腺炎的临床观察

The effect of insulin sensitivity with Telmisartan in patients with essential hypertension

目的:探讨替米沙坦对原发性高血压患者胰岛素敏感性的影响。方法:将60例原发性高血压并糖调节受损患者随机分成观察组和对照组,对照组常规使用卡托普利治疗,观察组使用替米沙坦40～80mg/d,治疗12w后,比较两组血压、空腹(FBG)及餐后血糖(2hBG)、空腹(FINS)及餐后血胰岛素(PINS)、胰岛素敏感指数(ISI)、胰岛素抵抗指数(HOMA-IR)和血脂的变化。结果:治疗12w后,观察组空腹血糖及餐后血糖、空腹及餐后血胰岛素、HOMA-IR显著降低,ISI显著升高,TG显著降低,与对照组比较差异有统计学意义(P<0.001),同时观察组收缩压和舒张压水平显著降低,与治疗前比较差异有统计学意义(P<0.001),但与对照组治疗后比较差异无统计学意义。结论:替米沙坦对原发性高血压患者胰岛素的敏感性具有增强作用,可改善原发性高血压患者胰岛素抵抗及降低甘油三脂,且优于卡托普利。

Objective Discussion the effect of insulin sensitivity with Telmisartan in patients with essentlal hypertension. Methods 60 cases of essential hypertension and surgar-balance damaged were randomly divided into test and control groups. Contral group used conventional treatment with captopril,and test group used Telmisartan 40-80mg qd . After 12 weeks treatment,two groups changes of systolic blood pressure(SBP) ,diastolic blood pressure(DBP) ,fasting blood glucose(FBG) ,2 hours postprandial blood glucose(2hBG) ,fasting blood insulin(FINS) ,postprandial blood insulin(PINS) ,insulin sensitive index(ISI) ,insulin resistance index(HOMA-IR) ,triglyceride(TG) ,total cholesterol(TC) ,high-dencity lipoprotein cholesterol(HDL-C) and low-density lipoprotein cholesterol(LDL-C) were compared. Results:After 12 weeks treatment,test group FBG、2hBG、FINS、PINS、HOMA-IR were significantly decreased,and ISI was significantly increased,but triglyceride(TG) was significantly decreased . Compared with the control group,there were significant differences,Also SBP and DBP level were significantly decreased and there were significant differences compared with the level before the treatment,but compared with control group after the treatment there were no significantly differences . Conclusions:Telmisartan was used in patitents with essential hypertension and surgar-balance damaged on insulin sensitivity act as enhanced role . Telmisartan is superior to captopril in improving insalin resistance with hypertensive patients and decreasing the level of TG .