布地奈德混悬液和硫酸特布他林雾化液雾化吸入治疗老年慢性阻塞性肺疾病急性加重期疗效分析

Clinical analyze of nebulized budesonide suspension combined with terbutaline sulphate to treat acute exacerbations in chronic obstructive pulmonary disease of elderly people

目的:探讨布地奈德混悬液和硫酸特布他林雾化液雾化吸入治疗老年慢性阻塞性肺疾病急性加重期的临床疗效。方法:选择80例AECOPD患者,随机分为观察组和对照组,两组例数相等,对照组采用基础治疗,观察组在基础治疗的基础上加用布地奈德混悬液和硫酸特布他林雾化液雾化吸入,比较两组疗效、肺功能改善和药物不良反应。结果:以显效和有效合并比较总有效率,观察组总有效率为77.5%,对照组总有效率为52.5%,雾化吸入治疗的效果明显优于基础治疗,差异显著(P<0.05);两组患者治疗后FEV1与治疗前比较均增加,雾化吸入治疗组FEV1提高较对照组更显著,差异有统计学意义(P<0.05);观察组患者在治疗过程中有6例出现药物不良反应,发生率为15%,对照组患者有5例出现药物不良反应,发生率为12.5%,无明显差异(P>0.05)。结论:布地奈德与硫酸特布他林联合雾化吸入治疗老年慢性阻塞性肺疾病急性加重期疗效显著,值得在临床推广应用。

Objective:to explore the clinical effect of nebulized budesonide suspension combined with terbutaline sulphate to treat acute exacerbations in chronic obstructive pulmonary disease of elderly people.Methods:select 80 AE-COPD patients and randomly divided into observation group and control group,the control group were treated with base method,on the base the observation group were treated with nebulized budesonide suspension combined with terbutaline sulphate,compare their treat effect,lung function improve and drug adverse.Results:the total effect of observation group is 77.5%,which of the control group is 52.5%,the difference is statistical significant(P<0.05);compare with before treating,FEV1 increased of the two groups after treating,but observation group is more obvious,the difference is statistical significant(P<0.05);6 of the observation group has drug adverse,the rate is 15%,while 5 of the control group has drug adverse,the rate is 12.5%,the difference is not obvious(P >0.05).Conclusion:nebulized budesonide suspension com-bined with terbutaline sulphate to treat acute exacerbations in chronic obstructive pulmonary disease of elderly people has good effect and can be widely used in clinic.