盐酸帕罗西汀治疗肠易激综合征疗效观察

Effect of Paroxetine Hydrochloride Therapy on Patients with Irritable Bowel Syndrome

目的评价小剂量抗抑郁药物盐酸帕罗西汀治疗肠易激综合征的疗效。 方法 36例符合罗马I诊断标准的肠易激综合征患者每日一次服用盐酸帕罗西汀 10mg,疗程 12周 ,治疗前后自身配对比较。 结果在胃肠道症状方面 ,对腹痛程度和腹痛天数 ,腹胀程度和腹胀天数及大便性状 (便秘或腹泻 )的改善具有明显疗效 (P <0 .0 5 )。但大便次数改善不明显。在精神和躯体症状方面 ,除了明显改善焦虑症状外 ,其它如抑郁、不愉快、疲惫、头痛及腰背痛症状改善不明显。 结论小剂量盐酸帕罗西汀能明显改善肠易激综合征患者的胃肠道症状 ,但在改善精神和躯体症状方面 。

Objective To assess the effect of small-dose antidepressant medication of paroxetine hydrochloride on irritable bowel syndrome (IBS). Methods In an open clinical trial, 36patients fulfilling Rome I criteria for IBS were treated for 12 weeks with paroxetine hydrochloride 10mg/d. Results Paroxetine hydrochloride could significantly improve gastrointestinal and psychogenic and psychosomatic symptoms of IBS, such as degree and duration of abdominal pain and abdominal distension, stool quality (constipation or diarrhea), as well as anxiety. Other symptoms such as stool frequency. depression, unhappiness fatigue, headache and low back pain were not much beneficial from this treatment. Conclusion Paroxetine hydrochloride can significantly improve gastrointestinal symptoms but not psychogenic and psychosomatic symptoms of IBS. It needs further study.