他汀类调脂药对冠心病患者C反应蛋白的影响

Effects of Statins on C-reactive Protein in Patients with Coronary Artery Disease

目的探讨他汀类调脂药对正常血脂的冠心病患者C反应蛋白 (CRP)的影响。 方法 6 0例未经调脂治疗具有正常胆固醇的冠心病患者 ,随机分为他汀类治疗组和对照组 ,前者给予普伐他汀 (15例 ,10mg d)或辛伐他汀(15例 ,2 0mg d) ,对照组未经调脂治疗。分别测定治疗前及 1年后的血CRP及血脂各项指标 ,并进行统计学分析。 结果他汀类治疗组患者CRP及LDL -C水平明显降低 ,治疗前后差异显著 ;对照组 1年后各项指标检查无明显变化。 结论两种他汀类药物不仅有调脂作用 。

Objective The aim of this study was to investigate whether statins can increase C-reactive protein in patients with normocholesterolemia. Methods The changes of CRP, cholesterol, HDL-cholesterol, LDL-cholesterol were observed. The relation of CRP and TC were analyed in 60 patients with coronay artery disease. Results CRP, LDL TC, TG were decreased, and HDL was inreased after treatment. Conclusion Statins not only can adjust lipid metabolism disturbance, but also have anti-inflammatory effects.