血浆降钙素原测定在肝硬化伴自发性细菌性腹膜炎患者中的临床应用

Application of plasma procalcitonin in cirrhotic patients with spontaneous bacterial peritonitis

目的 探讨血浆降钙素原 (procalcitonin ,PCT)对肝硬化伴自发性细菌性腹膜炎 (spontaneousbacterialperitonitis ,SBP)的诊断价值及与临床病程和预后的关系。方法 采用金标层析法测定 112例肝硬化腹水患者 (单纯腹水 5 1例 ,合并SBP 6 1例 )血浆PCT水平。结果 肝硬化腹水患者血浆PCT水平均显著高于正常 ,以 10ng/mL为阳性判断值时 ,SBP组阳性检出率显著高于无SBP组(P <0 0 0 1) ,且与培养是否阳性无关。最初三天血浆PCT水平变化与临床结局密切相关。结论 血浆PCT测定对肝硬化伴SBP的早期快速诊断及预后判断等有重要价值。

Aim To explore the diagnostic value of plasma procalcitonin(PCT) for spontaneous bacterial peritonitis(SBP) in liver cirrhosis,studying the relationship between it and clinical course,prognosis.Methods The plasma levels of PCT in 112 patients with cirrhotic ascites(61 with SBP and 51 without)were measured by gold immunochromatographic assay.Results Plasma levels of PCT significantly rose above normal value in all patients.The positive rate of PCT(>10ng/mL) was significantly higher in SBP group than that in no SBP group(P<0.001),and did not correlate with bacterial culture results.The variation of plasma PCT levels in the first three days significantly correlated with different outcome.Conclusions The detection of PCT has an important value in early diagnosis and judgement of prognosis of SBP in liver cirrhosis.