经肝动脉栓塞治疗转移性肝癌的方法探讨及疗效分析

Trans-hepatic arterial chemoembolization of meatastatlic liver cancer

目的探讨经肝动脉化疗并栓塞治疗转移性肝癌的方法及效果。方法180例转移性肝癌患者经造影后根据血供情况分别采用单纯灌注化疗(HAI)、化疗并用稠度不同的碘油化疗药乳剂栓塞治疗(TACE),并观察其临床效果。结果临床效果以肝癌和直肠癌肝内转移最佳,有效率分别为87.5%、84.3%。少血管型化疗栓塞组有效率为86.3%,明显高于单纯灌注化疗组的73%(P<0.01)。结论经肝动脉化疗栓塞是治疗转移性肝癌的一种有效方法,对少血供型患者采用稀碘油化疗药乳剂适量栓塞可以明显提高治疗效果。

Objective To investigate the method and the efficacy of hepatic arterial infusion (HAI)and trans-hepatic arterial chemoembolization(TACE)in the treatment of metastatic liver cancer(MLC).Methods According to the differences of blood supply in the lesions revealed by angiography,180 patients with clinically proved MLC underwent HAI and TACE,respectively.Results The efficacy of TACE for treatment primary liver cancer and metastatic liver cancer from rectal cancer was better than that for others,the effective rate was 87.5 % and 84.3 %,respectively.The therapeutic efficacy seen in chemotherapy plus embolization group(86.3 %)was obviously higher than that seen in single perfusion chemotherapy group(73.0 %)(P < 0.01).Conclusion TACE is a the most effective method for trantment of MLC,whereas ultra-fluidized lipiodol can prominently improve the therapeutic efficacy of embolization.