摘要
胃癌是我国肿瘤死因中占第一位的疾病,其发病原因至今还不甚清楚。流行病学资料认为与环境因素有关,而其中饮食因素是胃癌发生的最主要原因。近年的病因研究,认为N-亚硝基化合物与胃癌发生有密切联系。某些营养素的缺乏或不平衡,也可增加胃癌发生的危险性。流行病学研究资料还表明胃癌死亡率与人群硒水平成负相关。为了探讨硒、N-亚硝基化合物与胃癌发生的关系,我们进行了本次研究,报道如下。
The salenium levels in hair and serum and the concentration of nitrosamines ingastrio juice in 47 cases of patients with superficial gastritis (SG as NG),chronic atrophic gastritis (CAG), dysplasia (DYS) and gastric cancer (GC)were deter-mined and compared, and the nutrient intakes were also surveyed. The results showedthat the selenium levels in hair, serum and the intake also decreased in patients withCAG, Dys, and GC. The Se concentration in patients were NG>CAG>DYS>GC. Thedegree of Se decreasing levels followed the degree of pathologic change in gastricmucosa. The.concentration of the total volatile nitrosamine in gastric juice increasedfollowing the degree of pathologic change. By means of stepwise regression anslysis,wefound the concentration of nitrosamines in gnstrie juice is negatively related to thedaily intake of protein and calcium and hair selenium level, and is positively related tointake of iroh and Vitamin O. These illustrated that protein, caloium and seleniummight influence the synthesis of nitrosamines in stomach and nitrosamines mightinitiate gastric cancer.
出处
《肿瘤》
CAS
CSCD
北大核心
1991年第2期92-96,共5页
Tumor
