血浆和红细胞硒水平与大肠癌的关系

CHANGES OF PLASMA AND ERYTHROCYTE SELENIUM LEVELS IN PATIENTS WITH LARGE BOWEL CANCER

硒是体内一种必需微量元素,动物实验表明适当补充硒可减少化学诱癌发生率,并抑制移植性肿瘤的生长。流行病学的调查在美国和加拿大高硒地区消化道癌肿的死亡率明显低于低硒地区。Willett发现最低血硒浓度组患者发生癌的机会是最高血硒浓度组的2倍。Broghamer报道血硒水平与癌肿的生物学特性有一定关系,但血浆和红细胞硒水平与大肠癌及其浸润深度和扩散范围是否存在一定关联尚未见类似报道。本文测定不同人群组血浆和红细胞硒水平,分析硒值与大肠癌Dukes’病理分期之间的关系,并与正常人和非癌患者进行比较。

Selenium(Se) levels in plasma (μg/100ml) and erythrocyte (μg/100g Hb) weremeasured in 37 normal individuals, 50 large bowel cancer patients and 9 patients withother diseases by atomic absorption spectrophotometric method. Normal plasma and ery-throcyte Se were 25.9±9.4 and 55.3±3.0 respectively,there was no significant differ-ence of plasma and erythrocyte Se values between different age groups and sex groups(P>0.05). Plasma and erythrocyte Se levels for 25 colon cancer patients were 14.7±2 .8 and 35.4±4.2 respectively;for 25 rectal cancer patients, 14.9±2.2 and 31.7±3.6respectively;all significantly lower than those of normal person. There was no signifi-cant difference between Se levels of colon and rectal cancer patients,and no associationwith the extent of spread and depth of infiltration either. The results indicate that Sevalues in plasma and erythrocytes cannot predict extent of spread and depth of infiltra-tion of colorectal cancer,but low Se levels may be a contributory factor in the genesisand spread of colorectal cancer.