摘要
胃癌的早期发现,是提高胃癌患者生存期的关键。国外应用流式细胞分析术(Flow Cytometry,FCM)定量测定肿瘤细胞核DNA含量的异常改变与肿瘤生物学行为之间关系方面的研究,取得了较好的结果。本文在胃镜活检组织FCM检测的基础上,选择21例早期胃癌及癌旁胃组织存档标本进行FCM检测及回顾性分析,以冀探讨FCM在胃癌早期诊断及对其恶性程度估价中的应用价值。
DNA FCM was performed on fixed,embedded histological material from 21 radicalgastrectomies for gastrie cancer. 73 samples were measured by FCM. The normal gastrictissue block was used as a reliable external standard for cellular DNA content.20 samplesfrom gastric dysplasia near gastric cancer were measured by FCM. FCM results ofsevere dysplasia was akin to its of gastric cancer. Moderate and severe dysplasia must betreated as precancerous lesions. No relationship between gross pattern,tumor size,histo-logical classification and FCM results was observed. The result obtained from fresh samples by endoscopic biopsy of 15 cases with pro-gressed gastric cancer was similar to that of early cases No relationship between patho-logical stage and FCM results was observed in this study. The fact implied that theploidy level of carcinoma might be estimated in an early stage of tumor development anddid not change in the process of the tumor progression
出处
《肿瘤》
CAS
CSCD
北大核心
1991年第5期204-206,共3页
Tumor
基金
国家自然科学基金
