间羟基三氟甲苯的合成

Synthesis of 3-Hydroxytrifluorotoluene

以三氟甲苯为原料 ,经硝化、还原、重氮化、水解等过程 ,可以得到重要的农药中间体间羟基三氟甲苯 ,产物总收率达 70 %以上 ,在较高温度下进行重氮化反应时 ,可以显著提高间氨基三氟甲苯重氮化、水解反应的收率。

An important pesticides intermediate 3-hydroxytrifluorotoluene has been obtained from the raw material trifluorotoluene via nitration, reduction, diazotization and hydrolysis with the total yield over 70%.When diazotization carried out at higher temperature, the yield of diazotization hydrolysis of 3-amonotrifluorotoluene could be increased considerably.