肝癌组织间热疗临床病理初步报告

A PERLIMINARY REPORT ON THE CHINICAL PATHOLOGY OF THE PRIMARY HEPATIC CANCER TREATED WITH INTERTISSUE HYPERTHERMIA

本文报告了1986年12月至1988年5月,采用组织间射频(RF)热疗,治疗25例晚期原发性肝癌临床病理的结果。单纯热疗及热疗+放疗的一年生存存率高于外科组。热疗后的病理改变:急性期主要是炎症改变。慢性或晚期改变主要是瘤组织凝固性坏死,外围有纤维瘢痕组织包绕,形成一个完全的囊壁。坏死组织附近可见血管内血栓机化再通现象及新生的肝细胞大小不一,胞核增大,双核增多。从而提出了加热治疗晚期原发性肝癌的可行性及对评价热疗后的临床观察指标进行了探讨。

From December 1986 to May 1988, 25 cases of patient with late primary carcinoma of liver were treated with radio-frequency intertissue hyperthermia in our hospital. The survival rates of one year for single hyperthermia group aod hyperthermia plus radiation group were both higher than that for single surgery group. The clinical pathology of the heated liver was detailly discribed. The early reaction of the heated carcinomous tissue appeared mainly acute inflammation. And the late reaction be coagulation necrosis which was wholly surrounded by a lot of fibrotic tissues. Organition phenomenon of the intravascular thrombi and many newborn hepatic cells with varied volnm but bigger nucleus or double nuclei might be seen near the necrostic tissues. These demonstrated the benefit of heat treatment for the primary hepatic carcinoma. The clinical examination items for response evaluation after hyperthermia were also discussed.