氮甲为主治疗多发性骨髓瘤36例报告

RESULTS OF COMBINED CHEMOTHERAPY CONTAINING N-FORMYL SARCOLYSINE FOR 36 CASES OF MULTIPLE MYELOMA

本文报道用氮甲及氮甲为主联合化疗方案治疗36例多发性骨髓瘤。43程化疗的缓解率为49％,客观有效率68％,骨痛好转率达97％。1、3、5年生存率为89％、47％和33％。中位生存期35个月。副作用有胃肠反应和骨髓抑制。氮甲可作为治疗多发性骨髓瘤的首选药。

Thirty six patienis with multiple myeloma treated by combined chemotherapy containing N-formylsarcolysine (N-F) from 1960 to 1934 are reported. The response rate of entire group was 68％. The median remission time was 19 months. The 1, 3 and 5-year survival rates were 89％ (32/36) 47％ (17/36) and 33％ (12/36) respectively. The median survival time was 35 months. The effect of N-F was simillar with melphalan. The regimens containing N-F were especially good in relearing skeletal pain. The side effects of the regimens were gastro-intestinal reaction and myelosuppression, but they were mild.