肝癌家族微核率与遗传易感性关系的研究

STUDY ON MICRONUCLEUS FREQUENCY AND GENETIC SUSCEPTIBITY IN LIVER CANCER FAMILIES

本文应用微核技术,对肝癌患者50例,惠者一级亲属163例,对照者174例作了外周血淋巴细胞被核出现率测定,着重探讨微核与肝癌遗传的关系。结果表明:肝癌组与其他成员组相比、对照组与肝癌亲属各组相比均有极显著性差异(p<0.001),子代组与双亲,同胞组相比有显著性差异(p<0.05)。微核率与血缘有关.微核率的高低可作为不同人群致癌危险性的客观指标和评价依据.

Micronueleus frequency (MNF) in. peripheral blood lymphoeytes was tested among 50 patients with liver cancer, 163 cases of first-degree relatives of liver cancer patients and 174 controls by micronuc leus technology to study the relationship between liver cancer and heredity. The results showed that there were statistically significant differences between group of liver cancer patients: and controls and relatives of liver cancer patients (P<0.001). There was also a significant diffrence among children, parents and siblings (P<0.05). MNF was found to be associated with consannguinity. MNF may be considered as a marker to assess the risk of cancer in different populations.