摘要
应用免疫组化方法观察了胰腺癌PS-4相关抗原在117例手术切除胃癌标本及343例胃粘膜活检肠化标本中的表达。117例胃癌染色阳性93例,阳性率为79.5％。正常胃粘膜染色均为阴性。应用粘液组化技术将肠化分为Ⅰ、Ⅱ和Ⅲ型,发现Ⅲ型肠化PS-4抗原染色阳性率显著高于Ⅰ、Ⅱ型肠化(P<0.01),提示Ⅲ型肠化与胃癌关系密切。结果表明,检测胃粘膜组织中PS-4抗原对胃癌的诊断和胃癌高危患者的筛选可能有重要意义。
The expression of pancreatic cancer-related antigen PS-4 was investigated in 117 gastrectomy specimens of gastric caner and 343 biopsy specimens of intestinal metaplasia by immunohistochemical technique. Among the 117 cases of gastric cancer, 93 (79.5％) showed the positive reaction for PS-4 antigen, while no positive reaction was found in normal gastric mucosa. Intestinal metaplasia was classified into types Ⅰ, Ⅱ and Ⅲ by histochemical mucin stainings. In different types intestinal metaplasia, type Ⅲ exhibited a significantly higher positive rate for PS-4 antigen than types Ⅰ and Ⅱ (P<0.01), suggesting that typa Ⅲ intestinal metaplasia is cioseiy related to the histogenesis of gastric cancer. Our results indicate that PS-4 antigen may be valuable tumor marker in detecting gastric cancer and defining the highrisk group of gastric cancer.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1991年第3期139-141,共3页
Cancer Research on Prevention and Treatment
