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蛋白激酶C激活与胰岛素抵抗及糖尿病血管并发症 被引量：5

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摘要 蛋白激酶C(PKC)是一个由多基因编码的多功能同工酶家族 ,目前发现至少有 12种亚型。高血糖和游离脂肪酸可引起多种组织内二脂酰甘油 (DAG)水平升高 ,DAG可激活PKC。不同的PKC亚型可介导或抑制胰岛素的作用 ,促进葡萄糖代谢或引起胰岛素抵抗。研究表明 ,持续高血糖引起的DAG PKC系统激活与糖尿病多种血管并发症密切相关。选择性PKC β抑制剂LY3335 31在临床和动物实验中已取得满意疗效。
作者 石海燕 付方明 董砚虎
机构地区 青岛市内分泌糖尿病研究所暨糖尿病医院
出处 《国外医学（内分泌学分册）》 2002年第5期316-319,共4页 Foreign Medical Sciences(Section of Endocrinology)
关键词 血管并发症 二脂酰甘油 蛋白激酶C 胰岛素抵抗 糖尿病 PKC-β抑制剂
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献16

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同被引文献47

  • 1张荣,孟丽巍,张一飞,吕昌莲,郑秋艳,朱大岭.15-HETE对肺动脉平滑肌细胞钙离子浓度的影响[J].中国药理学通报,2005,21(1):66-69. 被引量：18
  • 2宋春红,李瑞峰.一氧化氮在2型糖尿病发病机制中的作用[J].中华内分泌代谢杂志,2005,21(1):88-90. 被引量：22
  • 3翟迎九,董雪红,周丽诺,胡仁明.STZ糖尿病大鼠心肌细胞凋亡及葡萄糖、血管紧张素Ⅱ、瘦素对心肌细胞凋亡影响的观察[J].复旦学报（医学版）,2005,32(3):330-332. 被引量：9
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  • 9Bareggi R,Grill V,Zweyer M,et al.Distribution of the extended family of protein kinaseC isoenzymes in fetal organs of mice:An immunohistochemical study[J].Cell TissueRes,1995,280(3):617-25.
  • 10Ha H,Yu M R,Choi Y J,et al.Activation of protein kinase C-delta and C-epsilon byoxditive stress in early diabetic rat kidney[J].AM J Kidney Dis,2001,38(4 Suppl 1):S204-7.

引证文献5

二级引证文献17

国外医学（内分泌学分册）
2002年 第5期

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