贮库组成对青蒿琥酯经皮渗透的影响

A Study on the Percutaneous Penetration of Artesunate from Various Reservoir Vehicles

目的 :通过对青蒿琥酯在不同贮库基质中的经皮渗透研究 ,确定影响其经皮渗透的主要因素 ,为青蒿琥酯透皮吸收制剂的研制提供有效数据。方法 :以透皮吸收速率常数和 12h累积渗透量为考察指标 ,应用正交设计追加试验法 ,探讨不同比例组成的IPA/Water/IPM、药物浓度及 pH值对青蒿琥酯经皮渗透影响。 结果 :药物浓度和pH值对青蒿琥酯的经皮渗透产生主要影响。结论 :适当组成的贮库基质可较好地促进青蒿琥酯的经皮渗透 ,若对其进一步研究 ,青蒿琥酯有望制成透皮吸收制剂。

Objective: To determine the main factors which affect the percutaneous penetration of artesunate and provide efficient data for the artesunate transdermal delivery system. Method: Transdermal speed constant and accumulative amount of 12 hours were used for the estimations of various reservior vehicles, and the supplement orthodox design was used to study the effect of pH, various proportion of IPA/Water/IPM, and drug concentration. Result: Drug concentration and pH were the main factors which affected the percutaneous penetration of artesunate. Conclusion: The suitable reservior vehicle can prompt the percutaneous penetration of artesunate, and artesunate TTS will be made with further studies.