肝血管平滑肌脂肪瘤八例报告

Hepatic angiomyolipoma:a report of eight cases

目的 探讨肝血管平滑肌脂肪瘤 (AML)的临床表现、诊断、治疗和预后。方法 对1989～ 2 0 0 0年间我院手术和病理学检查证实的 8例肝AML临床资料进行回顾性分析研究。结果男 3例 ,女 5例。发病年龄 2 5～ 5 9岁 (平均 39 6岁 )。肝左叶 3例 ,右叶 5例。 8例均行超声和CT检查。 2例行MRI检查。 2例行肝动脉造影。免疫组织化学染色 :肿瘤平滑肌样细胞表达HMB 4 5阳性。 8例均手术切除。除 1例死于术后心功能衰竭 ,其余 7例随访 9个月至 12年 ,未见肿瘤复发。结论 综合影像学检查有助于该肿瘤特征的显示和术前正确诊断。肿瘤平滑肌样细胞表达HMB4 5阳性 ,是诊断肝AML的可靠依据。手术切除是肝血管平滑肌脂肪瘤的有效治疗手段。

ObjectiveTo study the clinical feature, diagnosis, treatment and prognosis of hepatic angiomyolipoma.Methods The clinical materials of eight surgically treated patients with hepatic AML were retrospectively analyzed.ResultsThere were five females and three males, with age ranging from 25 to 59 years (mean 39 6 years). Tumors were located in the right lobe of the liver in 5 cases, and in the left lobe in 3 cases. Ultrasonography and computed tomography were performed in all cases. Magnetic resonance imaging and angiography were done in two each cases. The myoid cells in all tumors showed over expression of HMB 45. One patient died of postoperative heart failure, seven were followed up for 9 mos to 12 years without tumor recurrence. Conclusions Comprehensive imaging features can reveal the characteristic components of hepatic angiomyolipoma. HMB 45 immunostaining can be used to confirm the diagnosis. Surgical resection is an effective treatment of hepatic AML.