整合素αv亚基对肝细胞性肝癌血管生成、侵袭转移的影响

The effect of integrin αv subunit on the angiogenesis, invasiveness and metastasis of hepatocellular carcinoma

目的 研究整合素αv亚基 (αv)在原发性肝细胞癌 (HCC)中的表达情况及意义。方法对 4 3例HCC和 6例正常肝组织标本进行免疫组织化学染色 ,观察αv的表达与HCC的病理学特点、微血管密度 (MVD)之间的关系。结果 αv在肝癌细胞中的表达与肝癌卫星灶的形成密切相关 (H =9 0 0 8,P =0 0 0 3) ;αv在癌组织内皮细胞中阳性与阴性表达组的MVD值分别为 (15 1± 5 4 )和 (115±39) ,两组MVD的差异有显著意义 (t=2 5 0 3,P =0 0 16 )。结论 αv在HCC中的表达对肝癌的血管生成。

Objective To study the expression of integrin αv subunit(αv) in hepatocellular carcinoma(HCC )and its effect. Methods With the method of immunohistochemistry, specimens from 43 HCC patients and 6 control patients were studied. The relationship between the αv expression and pathological features,microvessel density(MVD) was evaluated.Results The difference of the expression of αv in tumor cells between HCC with satellite lesions and without it was significant(H=9 008, P =0 003).The MVD of HCC with positive and negative expression of αv in endothelia was 151±54 and 115±39 respectively,difference of which was significant( t =2 503, P =0 016).Conclusions Integrin αv subunit may play an important role in the angiogenesis, invasiveness and metastasis of hepatocellular carcinoma.