药物基因组学研究发展和前景分析

Current status and perspectives of pharmacogenomics:a review

药物基因组学是一个新的研究领域 ,旨在进一步阐明药物处置和药效个体差异的遗传特征 ,最终目的是为每个患者选择最佳药物疗法和剂量提供有力的科学依据。其遗传学特征还可为新药提供以机制为基础的研发手段。本文分析了该领域研究的现状与前景 ,并提出药物基因组学未来发展对策建议。

Pharmacogenomics is the burgeoning field of investigation that aims at further elucidation of the inherited nature of interindividual differences in drug disposition and effects, with the ultimate goal of providing a strongr scientific basis for selecting the optimal drug therapy and dosages for each patient. The genetic insights should also lead to mechanism_based approaches to the discovery and development of new medications. This review highlights the current status and perspectives of work in this field and addresses strategies that hold promise for future advances in pharmacogenomics.