146例成年汉族人血Leptin水平及其相关因素

Serum Leptin Concentrations in 146 Adult Chinese and Its Correlations

【目的】探讨一组广州地区成年汉族人血leptin水平与年龄、性别、BMI、血压、血糖和胰岛素等的关系。【方法】从本院体检人群中抽取 14 6例研究对象 ,其中男性 6 3例 ,女性 83例 ,肥胖者 (BMI≥ 2 5kg/m2 ) 4 2例 ,非肥胖者 10 4例。测定空腹血糖、血脂、胰岛素和leptin水平。【结果】 14 6名研究对象血leptin水平为 (0 90～ 31 2 5 ) μg/L ,平均 7 0 6 μg/L。血lep tin水平与BMI(r=0 36 3,P <0 0 1)、臀围 (r =0 389,P <0 0 1)和空腹胰岛素 (r =0 343,P <0 0 5 )呈正相关 ;肥胖组血lep tin水平比非肥胖组高 (9 85 μg/L vs6 17μg/L ,P <0 0 0 1) ;女性组血leptin水平比男性组约高 1 5倍 (10 75 μg/L vs4 0 6μg/L ,P <0 0 0 1)。【结论】本组成年汉族人血leptin水平与性别、BMI和空腹胰岛素相关 ,肥胖者存在leptin抵抗。

To study the relationship between serum leptin level and age, sex, BMI, blood pressure, serum glucose, insulin in Chinese. Anthropometry and fasting serum leptin, glucose, insulin concentrations were measured in 146 adult Chinese. Fasting serum leptin concentrations ranged from 0 90～31 25 μg/L, with geometric mean of 7 06 μg/L. The leptin concentrations were positively correlated with BMI(r=0 363, P<0 01), hip circumference(r=0 389, P<0 01) and fasting insulin concentrations(r=0 343, P<0 05) Serum leptin concentrations in the obese group were higher than that in the non obese group(9 85 μg/L vs 6 17 μg/L, P<0 001), and higher in women than in men (10 75 μg/L vs 4 06 μg/L, P<0 001) [Conclusion] Fasting serum leptin concentrations in Chinese are correlated with sex, BMI and fasting insulin concentrations. There is leptin resistance in obese subjects