静脉注射胺碘酮治疗急性心肌梗死伴发快速心房纤颤

Intravenous Amiodarone for Fast Atrial Fibrillation in Patients with Acute Myocardial Infarction

为观察静脉注射胺碘酮对急性心肌梗死 (AMI)伴发快速心房纤颤 (简称房颤 )患者的临床疗效 ,对 4 8例AMI伴新近发生快速房颤患者 ,静脉应用胺碘酮 ,观察房颤转复、心室率控制情况及不良反应。结果显示 ,4 8例患者用药后 1 5min、30min、1h、6h、2 4h心室率分别为 ( 1 0 7.1 7± 9.6 7)次 /min ,( 96 .0 0± 8.39)次 /min ,( 88.1 3± 9.98)次 /min ,( 79.88± 1 0 .1 9)次 /min ,( 74 .88± 9.80 )次 /min ,较用药前的 ( 1 30 .5 8± 9.1 5 )次 /min明显下降。 4 8例患者在 2 4h内均转为窦性心律 ,3例出现窦缓 ,1例为窦缓 +Ⅱ度Ⅱ型房室传导阻滞。

To determine the clinical efficacy of amiodarone in fast atrial fibrillation in patients with acute myocardial infarction, 48 acute myocardial infarction patients with recent onset of fast atrial fibrillation were observed. After an intravenous load, intravenous amiodarone was administered continuously. Efficacy of amiodarone in the reversion of atrial fibrillation and the control of ventricular rate as well as the side effects were observed. The ventricular rates of 15 min, 30 min, 1 h, 6 h, 24 h after the administration of amiodarone in the 48 patients were (107.17±9.67)beats/min, (96.00± 8.39)beats/min, (88.13±9.98)beats/min, (79.88±10.19)beats/min, (74.88±9.80)beats/min respectively, which were lower than the rate (130.58±9.15)beats/min before the drug was given. Atrial fibrillation was reverted to sinus rhythm within 24 h in 48 cases. Sinus bradycardia was observecd in 3 patients. Sinus bradycardia and Ⅱ°Ⅱ type AVB occurred in 1 patient. Intravenous amiodarone is effective and safe in the treatment of fast atrial fibrillation in patients with AMI.