肾移植受者巨细胞病毒感染与抗心磷脂抗体的关系

Relationship between cytomegalovirus infection and anticardiolipin antibody in renal transplant recipients

目的 探讨肾移植受者巨细胞病毒 (cy-tomegalovirus,CMV)感染与抗心磷脂抗体 (anticardiolipinantibody,ACA)产生的关系 .方法 肾移植受者 146例术后采用定性聚合酶链反应法 (PCR)检测 CMV- DNA,同时用酶联免疫吸附法 (EL ISA )检测血清抗心磷脂抗体免疫球蛋白 G(ACA- Ig G) ,并与正常对照组 (n=32 )进行比较 .结果 肾移植受者 146例 ACA阳性率为 17.1%,与正常对照 (6 .3%)无明显差异 ;而 CMV感染的肾移植受者 ACA阳性率为31.2 %,显著高于未感染 CMV的受者 (7.1%)及正常对照组(6 .3%,P<0 .0 1) .结论 肾移植受者 ACA的产生与 CMV感染密切相关 ,可能是 CMV导致移植肾慢性血管病变的原因之一 .

AIM To investigate the relationship between cytomegal ovirus (CMV) infection and the production of anticardiolipin antibody (ACA) in renal transplant recipients. METHODS Peripheral blood leukocytes from 146 renal transplant recipients were detected for CMV-DNA by polymerase chain reaction (PCR). Meanwhile, serum samples from these recipients and 32 age-matched healthy individuals were tested for ACA-IgG by enzyme-link immunosorbent assay (ELISA). RESULTS There were 25 cases (17.1%) of ACA (+) in renal transplant recipients and 2 cases (6.3%) of ACA (+) in control (P>0.05). The production of ACA in CMV infected recipients was higher than that in CMV non-infected recipients and the control. CONCLUSION There is a close relationship between CMV infection and the production of ACA in renal transplant recipients. It may be one of the mechanisms by which CMV induce renal allograft chronic vasculopathy.