外周血TNFα、NO与慢性肾衰竭的相关性

RELATIONSHIP BETWEEN PERIPHERAL BLOOD TNFα, NO AND CHRONIC RENAL FAILURE

目的 :研究肿瘤坏死因子 (TNFα)、一氧化氮 (NO)在慢性肾衰竭 (CRF)发病中的作用 ,及其与肾功能之间的关系。方法 :检测CRF患者外周血中TNFα、NO、SCr的水平 ,并与健康对照组比较。结果 :CRF患者外周血中TNFα、NO的含量明显高于正常对照组 (P <0 .0 1) ,TNFα与NO、SCr水平呈正相关 (P <0 .0 1) ,NO与SCr无相关性 (P >0 .0 5 )。结论 :TNFα、NO参与CRF的发病 ,提示TNFα可作为CRF患者预后的指标。

Objective:To investigate the relationship among tumor necrosis factor α(TNFα),nitric oxide(NO) and renal function,and study the clinical significance of TNFα and NO in CRF.Method:The serum creatinine(SCr),TNFα,NO levels of the patients with CRF and the healthy control group were determined and compared.Result:The contents of TNFα and NO in CRF patients were significantly higher than those of healthy control(P<0.01).There was positive correlation between NO or SCr level and TNFα level(P<0.01),while this correlation couldn′t be found between NO and SCr(P>0.05).Conclusion:TNFα and NO play an important role in CRF.It suggests that TNFα level can be used as a prognostic index for the renal function of CRF patients.