4种抗菌药物对淋球菌体外抗菌活性的研究

IN VITRO ANTIBACTERIAL ACTIVITIES OF FOUR ANTIBACTERIAL AGENTS TO NEISSERIA GONORRHEAE

本文采用琼脂倍比稀释法检测38株淋球菌对4种抗菌药物的敏感性,并作β-内酰胺酶测定.结果表明,21.1%的菌株对青霉素耐药;7.9%的菌株为PPNG;7.9%的菌株对壮观霉素耐药;而100%的菌株对氟嗪酸、氟哌酸敏感,且MIC_(50)、MIC_(90)值均低.结果显示,应注意淋球菌对青霉素、壮观霉素的耐药性,推荐用氟嗪酸。

In vitro susceptibilities of 38 strains of gonococcus to 4 antibacterial agents wers tested by the agar double dilution method.Beta-lactamase of the bacteria was also tested.The rusults showed that in 38 strains of gonococcus 21.1% were penicillin resistant, 7.9% were PPNG strains, 7.9%were spectinomycin resistant,all of them were susceptible to both ofloxalin and norfloxacin.The MIC50 and MIC90 of ofloxacin and norfloxacin were very low.It was indicated thaat much attention should be paid to the resistance of gorcccccus to penicillin and spectinomycin. Ofloxacin and norfloxacin should be recommended in treatment of gonorrhea