222例HBsAg携带者四年追踪观察

A FOLLOW-UP OBSERVATION OF 222 HBsAG CARRIERS OVER FOUR YEARS

对222例HBsAg携带者进行了四年动态观察.其血清学转归:HBsAg阴转46例,阴转率20.72%;HBeAg阴转25例,阴转率34.72%.其临床转归:康复46例.慢性携带者117例,急性肝炎12例,慢性肝病22例.轻微肝功能损害25例.影响转归的主要因素是HBsAg滴度、年龄及HBeAg-抗HBe系统.HBsAg、HBeAg阴转和HBsAg滴度呈负相关.和年龄呈正相关;HBeAg阳性者HBsAg阴转率低,且易倂各种急。

A follow-up observation of 222 HBsAg carriers was carried out over four years. The serological results showed that 46 out of 222 HBsAg carriers were negative converted (20.7%) , 25 out of 72 HBeAg positive carriers were negative converted (34.72%). The clinical results showed that 12 suffered from acute hepatitis, 10 from chronic persistent hepatitis (CPH), 8 chronic active hepatitis(CAH), 3 hepa-tocirrhosis, 1 primary hepatic carcinoma (PHC), 25 with slight liver function damage, 117 were asymptomatic carriers, and 46 persons recovered.This follow-up study indicated that the negative-conversion rate of HBsAg carriers with high titer or HBeAg positive was significantly lower than those with low titer or HBeAg negative and that the negative-conversion rate of HBsAg carriers or HBeAg positive increased with age