摘要
39例躁狂症病人分别单用锂盐或合并氯丙嗪治疗,在血药浓度达到稳态时及继续治疗四周后,两次测定血浆锂、钠和钾浓度,红细胞锂及锂比值;其中合并用药组第二次抽血时氯丙嗪平均已停用17±8.5天.发现单用锂盐组大多数(约83%)在病情好转或缓解后锂比值升高合用氯丙嗪可使红细胞锂平均升高31%,锂比值升高20%.血浆锂与红细胞锂及锂比值相互呈正相关(r=0.713,0.885及0.929,P<0.001).性别、家族史及血浆钠。
This paper reports 39 cases of manic patients treated with lithium carbonate or lithium carbonate plus chlorpromazine. Levels of plasma lithium, sodium and potassium, erythrocyte lithium and lithium ratio -were determined when the blood lithium had reached the steady state and continued 4 weeks of treatment respectively. The mean duration of ditcontinuing chlorpromazine at the second time of determination in the combined drug group was 17±8.5 days.We found most lithium treated patients (83%) who got improvement or remission showed elevation of their lithium ratio. On the average, chlorpromazine can increase the erythrocyte lithium by 31 % and lithium ratio by 20%. Plasma lithium, erythrocyte lithium and lithium ratio were in positive correlation. Sex, family history, Plasma sodium and potassium level showed no correlation with their lithium ratio
出处
《重庆医科大学学报》
CAS
CSCD
1991年第3期180-184,共5页
Journal of Chongqing Medical University
关键词
躁狂症
碳酸锂
锂比值
Mania
Lithium Ratio
Lithium Carbonate
Chlorpromazine
