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人类SSX基因族简介

Synopsis of Humam SSX Gene Family
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摘要 人类的SSX基因家族包括5个成员:SSXl,SSX2,SSX3,SSX4和SSX5,它们都位于X染色体上.这5个基因有很高的序列同源性:碱基序列有88%-95%同源;所编码188个氨基酸残基构成的蛋白质有77%-91%同源.它们所编码的蛋白质中含有KRAB(Kruppelassociatedbox).SSX蛋白质也是癌/睾丸抗原(CT:Cencer/testisantingns)中的成员.研究SSX基因结构、基因表达等对于肿瘤免疫疗法的建立具有重要意义. Human SSX gene family is comprised of five members, including SSX1 SSX2 SSX3 SSX4 and SSX5 genes. They are localized on the X chromosome. The SSX genes exhibit nucleotide homologies ranging from 88 to 95% and encode proteins(188aa) that exhibit homologies ranging from 77to 91%. The N-terminal portion of each SSX protein exhibits homology to the Kruppel - associated box (KRAB). The SSX proteins are members of still growing family of CT antigens (cancer/testis antigens). It is very important to study the structure and expression of SSX genes that may serve as targets to built and apply immunothera-py of all tumors.)
作者 侯万儒 任正隆
机构地区 四川师范学院 四川农业大学
出处 《四川师范学院学报（自然科学版）》 2002年第3期230-233,共4页 Journal of Sichuan Teachers College(Natural Science)
基金 四川省教育厅重点资助项目(2001-OILA51)
关键词 人类SSX基因族 基因家族 基因结构 基因表达 碱基序列 氨基酸残基 SSX gene family synopsis.
分类号 Q987.1 [生物学—遗传学]
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  • 2[2]CREW A J, CLARK J, FISHER C, et al.Fusion of SYT to Two Genes, SSX1 and SSX2, Encoding Proteins with Homology to the Krtüppel-Associated Box in Human Synovial Sarcoma[J]. EMBO, 1995, 14: 2333-2340.
  • 3[3]SHIPLEY J M, CLARK J, CREW A J, et al .The t(X;18)(p11.2;q11.2) Translocation Found in Human Synovial Sarcomas Involves two Distinct Loci on the X Chromosome[J]. Oncogene,1994,9(5):1447-53.
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四川师范学院学报（自然科学版）
2002年 第3期

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