支气管冲洗液及血清中乳铁蛋白测定的初步报告

ASSAY OF LACTOFERRIN IN BRONCHIAL WASHINGS

报告36例肺癌患者(腺癌14、鳞癌14、小细胞未分化癌8),212例肺感染患者(肺结核12、肺炎9),4例志愿者的BLF及40例正常人和上述三组的SLF放射免疫测定值。结果:SLF:肺癌组均值4.78μg/ml,显著高于正常组1．18μg/ml(p<0.05),但与感染组均值1.69μg/ml比较无差异;BLF:肺癌组均值53.95μg/ml,显著高于正常组4.05μg/ml及肺感染组15.44μg/ml(p<0.01)。如以20μg/ml为界值,肺癌组敏感性为67%,特异性86%。对腺癌敏感性为86%．可作为周围型肺癌早期诊断的参考。

Levels of lactoferrin in bronchial washing (BLR) were determined in 36 patients with bronchial carcinona (adenocarcinoma 14, Squamous cell carcinoma 14, small cell carcinoma 8), 21 patients with benign lung diseaso (taberculosis 12, pneumonitis 9), 4 normal volunteers and levels of LF in serum were determined in 40 healthy adults and alrove three groupe. Radioimmunaassay was used for the LF measurements. The average levels of SLF in 36 bronchial carcinoma Patients (4. 78±8. 87μg/m1) were signifi- cantly higher than that in healthy aduIts (1. 18±0. 81μg/ml) (P<0.05) but not significantly higher than those in benign lung disease (1. 69±0. 99μg/ml). The average levels of BLF in 36 bronchinl carcinoma patients (53. 95±47. 6μg/ml) were signifi- cantly higher than that in healthy adults (4. 05±3. 21μg/ml) and in benign lung diseases (15. 44 ±15. 79μg/ml) (p<0. 01). It was stipulated that the critical value between wa1ignant and benign lung diseases was 20μg/ml, the sensitivity of bnonchial carcinoma was 67 percent, speificity 86 per- cent, reliability 77 percent; the sensitivity of adenocarcinoma was 86 percent. The measurement of BLF may be considered as a reference parameter for early diagnasis of peripheral bronchial carcinoma.