泮托拉唑三联与奥美拉唑三联疗法根除幽门螺杆菌的对比研究

Comparison of pantoprazole and omeprazole-based triple therapy regimens in the treatment of Helicobacter pylori infection

目的 研究泮托拉唑三联疗法与奥美拉唑三联疗法及其 1周与 2周疗法根除幽门螺杆菌 (Helicobacterpylori,Hp)的效果。方法 14 7例经胃镜证实的Hp阳性的重度胃炎患者 ,随机分成泮托拉唑三联组 (n =82 )。 (泮托拉唑 4 0mg +阿莫西林 1g +甲硝唑 4 0 0mg,日 2次 ,疗程 1或 2周 )和奥美拉唑三联组 (n =6 5 ) (奥美拉唑 2 0mg +阿莫西林 1g +甲硝唑 4 0 0mg ,日 2次 ,疗程 1或 2周 )。疗程结束 4周后复查Hp ,观察Hp根除率、症状缓解率及不良反应等。结果 泮托拉唑三联与奥美拉唑三联疗法Hp根除率 1周分别为 85 7% (42 / 4 9)和 76 9% (2 0 / 2 6 ) ;2周为 93 9% (31/ 33)和 82 1%(32 / 39)。结论 泮托拉唑三联疗法 1周与 2周、奥美拉唑三联疗法 1周与 2周 4组之间比较差异均无显著意义 (P >0 0 5 )。

Objective To compare the efficacies of pantoprazole and omeprazole-based triple regimens in the treatment of H. pylori infection for 1-week or 2-week. Methods 147 patients with H. pylori associated gastritis were randomly divided into pantoprazole triple regimen group(pantoprazole 40 mg, amoxicillin 1 g, and metronidazole 400 mg, bid,for 1-week or 2-weeks) and omeprazole triple regimen (omeprazole 20 mg, amoxicillin 1 g, and metronidazole 400 mg, bid, for 1-week or 2-weeks). The eradication was determined by 13 C-UBT at least 4 weeks after antibiotic therapy. Results The eradication rate of H. pylori for 1-week pantoprazole triple regimen and omeprazole triple regimen were 85.7%(42/49) and 76.9%(20/26) respectively (P>0.05). The eradication rates of H.pylori for 2-weeks and pantoprazole triple regimen and omeprazole triple regimen were 93.9%(31/33) and 82.1%(32/39)for 2-week respectively(P>0.05). Conclusion The eradication rate of H. pylori in pantoprazole (or omerazole) triple therapy regimen for 2-weeks was higher than 1-week. However there were no significant difference between in these two groups(P>0.05). There were no significant difference between pantoprazole and omeprazole triple therapy regimen in eradication rate of H. pylori for 1-week or 2-weeks(P>0.05).