慢性肝病患者血清性激素的检测

DETERMINATION OF SERUM SEX HORMONES IN PATIENTS WITH CHRONIC LIVER DISEASES

对61例男性慢性肝病患者(其中肝硬化44例,慢性活动性肝炎13例,重型肝炎4例)用放射免疫法进行了性激素(雌酮E_(1)、雌二醇E_(2)和睾酮T)的测定,结果CAH患者的性激素均在正常范围内。肝硬化及重肝患者的E_(1)与CAH者无显著差异,肝硬化及重肝患者的E_(2)显著高于CAH者,T则显著低于CAH者(p均<0．01)．对男性肝硬化有无女性化体征者的性激素(E_(1)、E_(2)、T)进行了比较,均无显著差异(p均>0．05),而死亡病例的T显著低于存活病例(p<0．01)。

The serum sex hormones(E1,E2,T)of 61 male patients with chronic liver diseases (CAH 13 , liver cirrhosis 44 and sever hepatitis 4)were detected by RIA method . The sex hormones of CAH were in normal range . The conrentration of Ei in liver cirrhosis and severe hepatitis did not differ from that of CAH. But the concentrarion of Ez in LC and SH was significantly higher than that of CAH, and T in LC and SH was significantly lower than that of CAH. There was no significance in serum sex hormone in male liver cirrhosis with or without gy- necomastia and/or other gynecogenic signs.Whereas the concentration of T in dead cases was obviously lower than that of survivors (p<0. 01).