肝脏疾病患者血浆胍类化合物含量的变化

CHANGES OF GUANIDINO-COMPOUNDS IN THE PLASMA OF PATIENTS WITH VARIOUS LIVER DISEASES

作者采用安息香为柱前荧光衍生剂的高效液相层析法检测几种肝病患者血浆中胍类化合物的含量。结果表明,血浆中胍基乙酸在肝硬化等重症肝病时显著升高,在其它肝病时未见明显变化;血浆中其它胍类化合物在几种肝病时均未见明显的改变。肝病时血浆胍类化合物的变化与其它常见肝功能指标的变化没有显著相关性。

The levels of guanidino-compounds in the plasma of patients with various liver diseases were determined by high-performance liquid chromatography using benzoin as a pre-column fluorescent derivatization reagent. The results showed that the levels of guanidinoacetic acid (GAA) in plasma were significantly higher in patients with liver cirrhosis than those in normal human and other liver diseases, and that the levels of other guanidino -compounds in plasma of patients with various liver diseases were not significantly changed . There was no significant relationship between the levels of guanidino-compounds and common indicators for liver function in patients with various liver diseases.