感染性人工关节生物膜中细胞外多粘质物质对抗生素的影响

Effection of Extracellular Slime Substance from Infectious Biofilm of Prosthesis on Antibiotic

目的 :探讨感染性人工关节生物膜中细胞外多粘质物质 (ExtracellularSlimeSubstance ,ESS)对抗生素抑菌或杀菌作用的影响。方法 :利用人工关节的动物模型提取ESS ,通过药敏试验 (纸片扩散法 )测定ESS对抗生素菌环直径大小的影响。结果 :含有ESS的试验组的抑菌环的直径明显小于对照组的抑菌环的直径。结论 :ESS能明显降低抗生素的杀菌或抑菌作用。

Objective:Researching the effection of Extracellular Slime Substance(ESS)from infectious biofilm of prosthesis on antibiotic.Methods:Determing the infection of ESS from infectious prosthesis of animal model on the diameter of antiobiotic's inhibiting ring for bacterium.Results:The diameter of antibiotoic's inhibiting ring for bacterium being mixed with ESS was smaller than those without ESS.Conclusion:ESS could decrease antibiotic's function for killing or inhibiting bacterium.