采用γ照相机考察卡波姆934在狗体内的黏附性

The Investigation of Bioadhesive Property of Carbomer 934 by Gamma Camera in vivo

为研究卡波姆 934在狗消化道内的黏附性 ,采用放射性同位素 99m Tc标记卡波姆 934、乙基纤维素 ,用 γ射线闪烁扫描技术观察材料在胃肠道内的排空速度。结果表明 ,与非黏附材料 (乙基纤维素 )相比 ,黏附材料 (卡波姆 934 )在狗消化道各段的排空速度明显较慢。说明在狗体内 ,黏附性材料和非黏附性材料与胃小肠黏膜层的相互作用明显不同 ;卡波姆

To study bioadhesive property of carbomer 934 in dog alimentary tract, carbomer 934 and ethylcellulose were radiolabelled with technetium-99m. The gastrointestinal emptying rate of these materials was measured by the technique of gamma scintiscan. The results showed that the empty rate of adhesive material(carbomer 934) was remarkably slower in dog alimentary tract compared to nonadhesive material (ethylcellulose). It is concluded that, in dog, the interaction between gastrointestinal mucus layer and adhesive material or nonadhesive material was significantly different. Carbomer 934 had stronger bioadhesive property in vivo than that of ethylcellulose.