补髓生血颗粒对小鼠实验性再生障碍性贫血病理形态变化的影响

Effects of Busuishengxue Granules on the Pathomorphological Changes in the Mice with Experimental Aplastic Anemia

给小鼠腹腔注射马利兰 5周诱发骨髓损伤、造血功能障碍后 ,予补髓生血颗粒灌胃 3个月进行干预 ,通过外周血测定、骨髓涂片及活检观察 ,结果显示 :马利兰诱发的小鼠骨髓损伤符合再生障碍性贫血 (AA)的病理变化 ,补髓生血颗粒能显著地促进骨髓造血细胞及造血微环境结构修复 ,提高外周血红系造血细胞、粒系造血细胞、巨核系造血细胞水平。

First, the mice were given intraperitoneal injections of myleran for 5 weeks to induce their bone marrow injury and hematopoietic function disorder, and then, were given Busuishengxue Granules (BG) by gastric perfusion for 3 months for an intervention treatment. During the experiment, the mice were observed by peripheral blood test, bone marrow smear examination and biopsy. The results showed that the mouse bone marrow injury induced by myleran conformed to the pathologic changes manifested by aplastic anemia; and BG could significantly promote the repair of marrow hematopoietic cells and the structure of microcosmic hematopoietic environment, and increase the funtional levels of red cell series, granulocyte series and megakaryocytic series in the peripheral blood.