通脉益智胶囊抗动脉粥样硬化作用的实验研究

Experiment on the Effects of Tongmaiyizhi Capsules Against Atherosclerosis

观察通脉益智胶囊对实验性兔动脉粥样硬化的影响和作用。 2 1只健康雄性日本大白兔按体重随机分为 3组 ,实验全程 1 2周。结果 :与胆固醇造模组比较 ,通脉益智胶囊组实验动物兔血中总胆固醇、甘油三酯和低密度脂蛋白显著下降 ,高密度脂蛋白显著上升 ;血浆一氧化氮、全血谷胱甘肽过氧化物酶的含量明显升高 ,丙二醛显著下降 ;血栓素B2 明显降低 ,6 酮 前列腺素F1α有明显的上升趋势。同时通脉益智胶囊具有明显的减少实验动物兔主动脉及冠状动脉脂质沉着 ,缩小其斑块面积 ,保护主动脉内皮细胞的作用。结论 :通脉益智胶囊具有良好的抗动脉粥样硬化的作用 ,这可能与其调节血脂 ,减少氧化自由基损伤 ,调节血栓素B2 6 酮 前列腺素F1α平衡 ,保护内皮细胞有关。

The influence and effects of Tongmaiyizhi Capsules (TC) on rabbit experimental atherosclerosis were investigated in this experiment. 21 Healthy Japanese male rabbits were divided into 3 groups according to their body weight. The duration of the experiment was 12 weeks. The levels of blood lipid, NO, MDA, GSH Px, TXB 2 and 6 keto PGF 1α were detected during the experiment. The pathologic changes in the rabbit aorta, coronary artery and middle cerebral artery were observed by the optical microscopy, and the pathologic changes in the rabbit aortal endothelial cells were observed by the scanning electron microscopy. The results showed that as compared with those in the animals in the cholesterol induced model group, in the TC treated group, the levels of blood total cholesterol, triglyceride and LDL were significantly decreased, and the level of HDL was significantly increased; the levels of blood NO and GSH Px were markedly increased, and the level of MDA was markedly decreased; the level of blood TXB 2 was remarkably decreased, and an obvious increasing tendency was found with the level of 6 keto PGF 1α . The results also showed that TC could significantly reduce the fat deposit in the rabbit aorta and coronary artery, diminish the plague area and protect aortal endothelial cells.