胰腺癌患者血清十二种肿瘤标记物的变化

The changes of twelve tumor markers levels in sera of patients with pancreatic cancer

目的 探讨定量测定胰腺癌患者血清12种肿瘤标志物的临床意义。方法 用蛋白芯片技术定量测定42例正常人、30例胰腺癌和16例胰腺炎患者血清12种肿瘤标志物的变化并对检测效果进行评价。结果 42例正常人血清CA19-9(KU/L)、NSE(μg/L)、CEA(μg/L)、CA242(KU/L)、Ferritin(μg/L)、β-HCG(μg/L)、AFP(μg/L)、f-PSA(μg/L)、PSA(μg/L)、CA125(KU/L)、HGH(μg/L)和CA153(KU/L)的含量分别为:12.42±10.62、2.24±1.41、1.78±1.04、5.73±5.67、91.17±78.47、0.64±0.33、2.96±3.89、0.13±0.11、0.62±1.38、5.46±9.53、1.63±2.37、9.83±9.40;30例胰腺癌患者血清12种肿瘤标志物含量依次为:279.47±402.0、9.50±11.30、8.57±21.95、98.23±89.33、301.98±216.63、1.49±2.28、5.50±7.69、0.27±0.62、1,62±3.23、167.16±252.49、3.38±8.38、43.22±99.34;16例胰腺炎患者其含量依次为:53.38±86.38、12.78±28.50、1.20±0.94、22.99±51.13、343.43±308.27、3.63±11.99、5.09±3.66、0.10±1.32、0.66±0.61、98.67±212.23、1.79±1.63、4.15±2.13。该蛋白芯片测定的敏感性为70.0％,特异性为89.7％,阳性预测值为77.8％,阴性预测值为88.1％。结论 采用蛋白芯片技术同时测定患者血清中多种肿?

Objective To study the clinical significance of serum 12 tumor markers levels in patients with pancreatic cancer. Methods The values of serum 12 tumor markers were detected by a proteinchip in 42 controls, 30 pancreatic cancers and 16 pancreatitis. The clinical effect of using the proteinchip was evaluated. Results Serum levels of CA19-9(KU/L), NSE(μg/L), CEA(μg/L), CA242(KU/L), Ferritin (μg/L) , β-HCG (μg/L), AFP(μg/L), f-PSA(μg/L), PSA(μ g/L), CA125 ( KU/L), HGH(g/L)and CA153(KU/L) were 12. 42 ± 10. 62, 2. 24±1. 41, 1. 78 ± 1. 04, 5. 73 ± 5.67, 91.17 ± 78.47, 0.64 ±0.33,2.96±3.89,0.13±0.11,0.62±1.38,5.46±9. 53, 1.63 ± 2.37 and 9. 83 ± 9. 40 in controls, 279. 47 ± 402. 0, 9. 50±11. 30, 8. 57 ± 21. 95, 98. 23 ± 89. 33, 301. 98 ± 216. 63, 1. 49 ± 2. 28, 5. 50 ± 7. 69, 0. 27 ± 0. 62, 1. 62 ± 3. 23, 167. 16 ± 252. 49, 3. 38 ± 8. 38 and 43. 22±99. 34 in 30 pancreatic cancer, 53. 38 ± 86. 38, 12. 78 ± 28. 50, 1. 20 ± 0. 94, 22. 99 ± 51. 13, 343.43 ± 308.27, 3.63 ± 11.99, 5.09 ± 3.66, 0.10 ± 1.32, 0.66 ± 0.61, 98.67 ± 212.23, 1.79 ± 1.63 and 4. 15 ± 2. 13 in 16 pancreatitis, respectively. The sensitivity and specificity, positive and negative predictive values of the proteinchip determination were 70. 0%, 89. 7%, 77. 8% and 88. 1%, respectively. Conclusions Multi-tumor markers levels in serum can be detected by using proteinchip. The proteinchip was proved to be useful in survey and observation of curative effect for patients with carcinoma.