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NF-kB:急性胰腺炎研究中的新热点

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摘要 近年来,随着对急性胰腺炎尤其是急性重症胰腺炎发病机制认识的不断深入,"白细胞过度激活学说"日益引起人们的重视,而细胞因子在白细胞过度激活以及由此导致的全身炎症反应综合征中起着极其重要的作用.核因子-kappaB(NF-κB)是一个广泛存在于细胞中具有多向性转录调节作用的蛋白质因子,它能与多种细胞因子、粘附分子基因启动子部位的κB位点发生结合,增强这些基因的转录和表达,导致TNF、IL-1、IL-6、IL-8、ICAM-1、P-selectin等基因的过度表达,本文综述NF-κB蛋白的结构与功能及其在急性胰腺炎发病中的作用,为急性胰腺炎的研究提供一条新的思路和治疗手段.
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出处 《胰腺病学》 2002年第3期182-183,共2页 Chinese JOurnal of Pancreatology
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参考文献17

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