川芎嗪对急性心肌梗死大鼠血浆TXB_2、6-Keto-PGF1α的影响

Effects of Tetramethylpyrazine on the Contents of TXB_2 and 6-Keto-PGF1α in Plasma of Rats with Acute Myocardial Infarction

目的研究川芎嗪 (TMP)对急性心肌梗死 (AMI)大鼠的心梗面积及血浆中TXB2 、6 Keto PGF1α含量的影响。方法制备大鼠AMI模型 ,腹腔注射 (ip)不同剂量的TMP ,3天后从鼠股动脉取血。采用免疫组织化学方法检测血浆中TXB2 、6 -Keto -PGF1α的含量。结果与生理盐水对照组比较TMP( 2 0mg·kg- 1～ 6 0mg·kg- 1,ip) ,血浆中TXB2 含量明显降低 ,血浆中 6 Keto PGF1α的含量明显升高 (P <0 .0 1 ) ,心梗面积明显减少 (P <0 .0 1 )。结论AMI大鼠血浆中TXB2 、6 Keto PGF1α含量的变化可能是AMI发生的重要体液因素 ,TMP(ip)可减少心梗面积并对血浆中TXB2 及 6 Keto

Objective To study the effects of tetramethylpyrazine (TMP) on the contents of TXB 2 and 6-Keto-PGF1α in plasma of rats with acute myocardial infarction(AMI).Methods The AMI models of rats were established.Using immunogistochemical method detecte the contents of plasma TXB 2 and 6-Keto-PGF1α and measure the infarct sizes of in all rats.Results Comparing with saline group,in TMP group (20mg·kg -1 ～60mg·kg -1 ,ip) the infarct size had reduced,the contents of plasma TXB 2 had droped and the contents of plasma 6-Keto-PGF1α had increased significantly.Conclusion The variations of TXB 2 and 6-Keto-PGF1α contents might be an important humoral factor for the onset of AMI.The TMP (ip) had favorable effects to adjust those contents and reduce the infarct size.