巨细胞病毒感染对甲型肝炎患儿血清及唾液中抗HAV-IgM检出率的影响及意义

Effects of Cytomegalovirus Infection in Serum and Salvia of Children with Hepatitis A on Anti-HAV-IgM

目的 :研究巨细胞病毒感染对甲型肝炎患儿血清及唾液中抗HAV -IgM的影响。 方法 :在 5 1例急性黄疸型肝炎 (急黄甲肝 )合并巨细胞病毒 (CMV)感染的患儿中 ,于病程 10d内、1～ 3月、3～ 6月同时检测血清和唾液中抗HAV -IgM。 结果 :原发性CMV感染者 1～ 3月的唾液抗HAV -IgM检出率明显高于血清检出率 (10 0 % ,37.5 % ,P =0 .0 11) ,活动性CMV感染者唾液中抗CMV -IgM检出率显著高于非活动组及 4例单纯急黄甲肝者。结论 :唾液中抗HAV -IgM可能不直接来自血浆 ,更具临床检测价值 ,活动性CMV感染可延缓唾液中抗HAV

Objective To study the effect of CMV on HAV-lgM of the serum and the saliva in patient with acute hepatitis A. Methods Of 51 cases with acute hepatitis A and cytomegalovirus(CMV) anti-HAV-IgM in the Serum and the saliva was tested at period of 10 days, 1-3 months and 3-6 months. ResultsAnti-HAV-IgM positive rate in the saliva was higher than that in the serum (100% and 37.5% respectively P =0.011), during the 1-3 month period in the patient with primary CMV infection, and that anti-CMV-IgM positive rate in the saliva in the patient with active CMV infection is higher than that in the nonactive patients and that in the 4 cases with an acute and single hepatitis A. Conclusion Anti-HAV-IgM in the saliva is not from the serum, and has clinical significance. Active CMV infection can postpone the elimination of anti-HAV-IgM in the saliva.