急性淋巴细胞白血病免疫分型的检测意义

Significance of acute lymphoblastic leukemia by immunologic subtype

目的:分析免疫分型在急性淋巴细胞白血病 (AL L )诊断分型中的意义。 方法:采用单克隆抗体方法 ,对 6 2例 AL L 进行免疫分型。结果 :细胞化学染色表现为 POX阴性或 <3% ;NSE(- ) ;免疫分型表现普通型 AL L31例中 ,前前 B- AL L 10例 ,前 B- AL L 6例 ,T- AL L 9例 ,T/ B混合型 6例 ,并对其进行了临床分析。在 6 2例 AL L中 ,有 8例同时表现髓系抗原 (My+ )增高 (CD33+ 3例 ,CD1 3+ 2例 ,CD1 3+ +CD1 4+ 1例 ,CD1 3+ +CD33+ 1例 ,CD1 4+ 1例 )。发现前前 B- AL L、T- AL L、T/ B混合型及 My+ - AL L 预后较差。 结论 :AL L 的免疫分型与临床表现、治疗反应。

Objective: To analyse the role of immunophenotypic markers in classification of acute lymphocytic leukemia (ALL). Methods: The immunophenotype of 62 cases of lymphocytic leukemias were studied by using a panel of monoclonal antibodies (McAbs). Result: 62 cases with ALL diagnosed according to the criteria of the peroxides staining negtive, NSE staining negtive. 31 cases wers defined as cALL, 10 cases as early pre B ALL, 6 cases as pre B ALL, 9 cases as T ALL and 6 cases as T/B Mixed ALL. 8 in the 62 cases with ALL immunology also had the myelogenous antigens expressed;of them. 6 cases had only one subtype,2 had 2 subtypes. We found that the poor prognosis associated withe early pre B ALL, T ALL, Mixed ALL and My\++ ALL. Conclusion: The immunologic subtye of ALL is related with clinical manifestation, response of therapy, remission rate and survival duration.