急性白血病多药耐药性检测分析

Detection of multidrug resistence in acute leukemia

目的:探讨 P1 70 表达与临床特征及化疗疗效的关系。 方法 :用间接免疫荧光法检测 175例急性白血病的 P1 70 表达 ,ANL L 12 9例 ,AL L 4 6例。分为 3组 :初治组 12 0例 ,完全缓解组 36例 ,复发难治组 19例 ,结合预后及临床特征进行综合分析。结果:初治组、完全缓解组 (CR)、复发难治组中 P1 70 的表达阳性率分别为 11.7%、16 .7%、5 7.8% ,其中初治组与复发难治组、完全缓解组与复发难治组相比较差别均有显著性意义 (P =0 .0 0 0 0和 P =0 .0 0 16 )。 结论 :P1 70 表达与患者的性别、年龄及 FAB分型等无关 ,与预后密切相关 。

Objective: To detect the relationship between the expression of P 170 and clinical chemotherapeutic effects. Methods: Indirect immunofluorescence was used to detect the expression of P 170 in leukemia cells from 175 AL patients. Results: Positive expression rates in newly diagnosed patients, complete remession(CR) patients and relapsed or refractory patients were 11.7%, 16.7 % and 57.8% respectively. Moreover, the difference, between newly diagnosed patients and relapsed or refractory patients were significant (P=0.000 0 and P=0.001 6). Conclusions: The expression of P 170 had no relation to sex, age, FAB subtype, but was immediately related with prognosis, and may offer as an independent poor indicator for prognosis.