男性心绞痛及心肌梗死患者血中TXB_2、ET、SOD浓度变化分析

Analysis of changes of blood TXB_2, ET, SOD levels in MI and angina patients

目的:研究心绞痛和心肌梗死患者血中血栓素 B2 (TXB2 )、内皮素 (ET)、超氧化物歧化酶 (SOD)浓度的变化。方法 :结合选择性冠状动脉造影术 (CAG)、静息 99m Tc- MIBI心肌灌注断层显像 (SPECT)及临床诊断 ,将 4 8例男性患者分为心绞痛组 (15例 )、心肌梗死组 (18例 )及非器质性心脏病组 (15例 ) ,分别比较 3组血中 TXB2 、ET、SOD浓度差别。 结果 :3种生物活性物质比较中 ,仅发现心肌梗死组较非器质性心脏病组血浆 ET浓度升高有统计学意义。

Objective: To analyse the changes of plasma thromboxane B\-2(TXB\-2), endotheline(ET), and serum superoxide dismutase(SOD) levels in patients with myocardial infarction(MI) and angina pectoris. Methods: Based on coronary angiography(CAG), Rest 99m Tc MIBI SPECT and clinical diagnosis, 48 patients were classified into MI group(18 cases) , angina group (15 cases) and non organic heart disease group(15 cases). Levels of three biological active substances(TXB\-2, ET, SOD) were compared between MI group, angina group and control group, respectively. Results: ET content in MI group were significantly higher than the control group. Conclusion: MI can increase plasma ET content.