东莨菪碱对大鼠癫疒间持续状态后脑水肿的影响

Scopolamin Hydrobromidum Attenuates Cerebral Edema Followed Statas Epilepticus in Rats

目的 :观察东莨菪碱能否改善癫持续状态后引起的脑水肿。方法 :2 %戊四氮 112mg·kg-1大鼠皮下注射制作全身性癫持续状态模型 ,发作 45min后 ,腹腔注射药物 ,干显重法测脑水分含量。结果 :癫持续状态 45min后存在轻度脑水肿 ,东莨菪碱与地西泮联合应用可减轻发作后脑水肿 ,地西泮单独应用不能减轻发作后脑水肿。结论 :东莨菪碱和地西泮联合应用治疗癫持续状态 ,不仅具有抗癫作用 。

Aim:To observe the attenuation of cerebral edema followed statas epilepticus by scopolamin hydrobromidum. Methods:The models of statas epilepticus in rats were established by subcutaneous injection of 2% pentylenetetrazol(112 mg·kg -1 ) in rats. The medication was administered to introperitoneal 45 min after statas epilepticus seizure. Brain water content was determined by the wet and dry weighting method. Results:The mild cerebral edema was developed 45 min after statas epilepticus. Intervention with scopolamin hydrobromidum combined with diazepam could attenuate cerebral edema followed the seizure. But diazepam had no such function. Conclusion:The treatment of combined scopolamin hydrobromidum with diazepam not only restrained seizure of statas epilepticus. but also attenuated cerebral edema followed seizure.