根治性手术对结直肠癌患者血清IL-13和VEGF表达水平的影响

The effect of Radical surgery to the expression of IL-13 and VEGF in patients with colorectal cancer

目的探讨根治性手术对结直肠癌患者血清中白细胞介素13(IL-13)和血管内皮生长因子(VEGF)表达水平的影响。方法选取我院2012.1~2014.12收治的68例结直肠癌患者及进行体检的30例健康人群采血。收集的所有血清标本均检测IL-13和VEGF的表达水平并记录。结果结直肠癌患者术前、术后血清中各指标水平呈平行升高的关系,且与对照组比较差异具有统计学意义(P<0.05);经施行根治性手术后,各指标表达明显下降,但高于对照组,差异具有统计学意义(P<0.05)。结论 IL-13、VEGF在结直肠癌患者血清中平行升高,根治性手术能够显著降低患者血清IL-13、VEGF的水平。

Objective To investigate the effect of radical operation on the expression of IL-13 and VEGF in serum of patients with colorectal cancer.Methods 68 patients with colorectal cancer and 30 healthy people who were treated in our hospital from 2012.1~2014.12 were collected.All serum samples were collected to detect the expression levels of VEGF and IL-13 and were recorded.Results The preoperative and postoperative serum levels of patients with rectal cancer were significantly different from those of the control group(P<0.05),and the expression of each index was significantly lower than that in control group(P<0.05).Conclusions IL-13 and VEGF were elevated in serum of patients with colorectal cancer,and the level of serum IL-13 and VEGF were significantly lower in patients with radical operation.