FOLFOX6对大肠癌根治术后患者血清IL-17、MMP-9、CEA的影响及相关性分析

The influence and their correlation analysis of IL-17,MMP-9,CEA in serum of patients with colorectal cancer after radical operation by FOLFOX6

目的探讨FOLFOX6对大肠癌根治术后患者血清IL-17、MMP-9、CEA的影响及相关性。方法 76例接受根治术的大肠癌患者为大肠癌组,并分为常规化疗组(CC组)和FOLFOX6组(FF组),每组均38名;选取健康体检者26例为对照组(C组)。ELISA法检测血清IL-17、MMP-9、CEA水平。结果与C组比较,CC组和FF组血清IL-17、MMP-9、CEA表达水平升高;与B1比较,CC组和FF组血清IL-17、MMP-9、CEA表达水平下降,且FF组较CC组更明显,P<0.05。结论 FOLFOX6能显著降低大肠癌根治术患者血清IL-17、MMP-9、CEA表达水平。

Objective To investigate the FOLFOX6 for colorectal cancer patients serum IL-17,MMP-9,and the related impact of CEA.Methods 76 cases of colorectal cancer who underwent radical surgery in patients with colorectal cancer group and divided into the conventional chemotherapy group(CC group)and FOLFOX6group(FF group)were 38;choose healthy 26 cases in the control group(C group).ELISA was used to detect serum IL-17,MMP-9,CEA levels.Results Compared with group C,CC and FF group serum IL-17,MMP-9,elevated levels of CEA expression;compared with B1,CC group and FF serum IL-17,MMP-9,CEA expression levels drop,and FF group than CC group more significantly,P<0.05.Conclusion FOLFOX6 can significantly reduce colorectal cancer surgery patients serum IL-17,MMP-9,CEA expression levels.