我院狂犬疫苗不良反应监测与分析

Monitoring and analysis of adverse reactions caused by rabies vaccine

目的:观察注射狂犬疫苗后出现的不良反应。方法:对我院2000年8月～2001年10月注射狂犬疫苗1152人次中发生不良反应者进行调查。结果:注射狂犬疫苗患者中有12例(男1,女11)自感不适,不良反应发生率为1.04％。首次注射即发生8例,第2次注射后发生3例,注射3次以上者发生1例。症状表现各异,例如,局部硬结、全身荨麻疹、眩晕、发热等。其中轻度4例,中度6例,重度2例。结论:狂犬疫苗能引起不良反应,监测工作不容忽视。

Objective: To observe adverse reactions associated with rabies vaccine. Method: From August 2000 to October 2001, 1152 visits of outpatients were injected with rabies vaccine in our hospital and resulting reactions were surveyed. Results: Adverse reactions appeared in 12 cases, male 1 and female 11, accounting for 1.04% and happening after first injection of vaccine (8 cases), second injection (3) or over three injections (1). The manifestations varied from mild (4 cases) to moderate (6) to severe (2), such as local induration, general urticaria, dizziness, fever and the like. Conclusion: Rabies vaccine could cause adverse reactions, so the monitoring after its injection is important for professional practices.