高血压家族史人群隐匿性高血压发生情况及对靶器官损害程度的研究

Study on occurrence of masked hypertension and the degree of target organ damage in the population with family history of hypertension

目的 探讨有高血压家族史人群隐匿性高血压发生情况及对靶器官的损害程度。方法经医院伦理委员会批准,连续入选2017年1月至11月在本院体检的987例有高血压家族史受试者作为观察组。同时抽取同期在本院体检的既往无高血压家族史受试者987例作为对照组。观察两组隐匿性高血压的发生率及左室质量指数(LVMI)和颈动脉内-中膜厚度(IMT)。结果 观察组高血压和隐匿性高血压发生率与对照组比较均明显升高,差异有统计学意义(P <0. 05)。隐匿性高血压组患者LVMI和IMT均明显高于正常血压组,高血压组患者LVMI和IMT均高于隐匿性高血压和正常血压组,且家族史阳性隐匿性高血压患者LVMI和IMT均高于家族史阴性患者,差异均有统计学意义(P <0. 05)。结论 高血压家族史可增加隐匿性高血压的发生率和患者的器官损害,对有高血压家族史者应加强隐匿性高血压的监测。

Objective To investigate the occurrence of masked hypertension(MH)and the degree of damage to target organs in people with family history of hypertension.Methods 987 cases of family history of hypertension who had been examined in our hospital from January 2017 to November 2017 were selected as observation group with the approval of hospital ethics committee.At the same time,987 subjects without family history of hypertension who had been examined in our hospital during the same period were selected as control group.The incidence of masked hypertension,left ventricular mass index(LVMI)and carotid intima-media thickness(IMT)were observed.Results The incidence of hypertension and masked hypertension in the observation group was significantly higher than that in the control group(P<0.05).LVMI and IMT in patients with masked hypertension were significantly higher than those in normal blood pressure group.LVMI and IMT in patients with hypertension were higher than those in patients with masked hypertension and normal blood pressure group.The LVMI and IMT of patients with family history of masked hypertension were higher than those without family history of masked hypertension.Conclusions Family history of hypertension can increase the incidence of masked hypertension and organ damage of patients.The monitoring of masked hypertension should be strengthened for those with family history of hypertension.