NF-κB在神经性病理疼痛中的作用研究进展

Research progress in the role of nuclear factor-kappa B in neuropathic pain

慢性疼痛是一个全球性的公共健康问题,其中由神经损伤造成的神经性病理疼痛(NP)是最常见的慢性疼痛。目前,无论何种原因引起的NP均缺乏有效的治疗。近年来,越来越多的研究表明神经免疫、神经炎症在介导NP中起着关键作用,而核因子-κappa B(NF-κB)在免疫和炎症系统中对疼痛诱导物和效应物的表达发挥着极为重要的作用。研究表明NF-κB可通过结合多种炎症因子的启动子促进它们转录上调。本文就NF-κB在NP中的作用的研究现状作一综述。

Chronic pain is a worldwide public health problem in which neuropathic pain(NP)caused by nerve damage is the most common chronic pain.At present,NP lacks effective treatment for any reason.In recent years,increasing studies have shown that neuroimmunity and neuroinflammation play a key role in mediating NP,and nuclear factor-kappa B(NF-κB)plays the most important role in the expression of pain inducers and effectors in the immune and inflammatory systems.NF-κB promotes transcriptional up-regulation by a promoter that links to a variety of inflammatory factors.Therefore,this paper reviews the research status of the role of NF-κB in NP.