大剂量睾酮对雌性小鼠肾损伤的组织学和形态计量学研究

A histological and morphometrical study of large dosage of testosterone on renal damage of female mice

临床上应用雄激素（睾酮）治疗功能性子宫出血，子宫肌瘤和慢性肾病等，用量大，疗程长，且能引起肾功能障碍。为了阐明肾损伤的病理组织学基础，我们给雌性小鼠以大剂量雄激素，用光镜和电镜观察了肾脏的病理组织学和超微病理学改变，并测定了肾小体、血管球和肾小管的形态计量学参数，结果显示：肾小体和肾小管，特别是滤过膜和近曲小管上皮均有十分明显的细胞和亚细胞水平改变；近曲小管的截面积、等效体积、周长、最大直径、最小直径、等效直径和形状因子等７项参数与正常对照组相比，也有十分显著的差异。因此。

Usually,androgen (testosterone )is clinically used to treat functional metrorrhagia, hysteromyoma and chronic renal diseases. The dosage is large, the course of treatment long, and it may cause disturbance in renal function. In order to explain the pathohistological basis of renal damages, large doses of androgen were given to female mice and observed with optical and electron microscopes and morphometrical parameters. The results showed very apparent cellular and sub-cellular changes in the corpuscula renis and renal tubules, especially in the filter membrane and the epithelium of the proximal convoluted tubules. And there were also very apparent differences in the seven parameters of the proximal convoluted tubules in comparison with the normal control group. Therefore, when large doses of androgen are administered for a long time, its damages to the kidney should be kept in mind.