直肠癌中VEGF与PCNA的表达及其临床意义

The expression of VEGF and PCNA in rectal cancer and its clinical significance

目的 通过检测直肠癌中VEGF及PCNA的表达 ,探讨其对直肠癌的发生、发展及其对预后的意义。方法 应用免疫组化S P法 ,检测直肠癌中VEGF及PCNA的表达。结合组织学分类、淋巴结转移等分析。结果 正常结肠粘膜中VEGF及PCNA的阳性率分别为 15 .4 %及 6 .7% ,直肠腺瘤中VEGF及PCNA的阳性率分别为 16 %及 2 8% ,直肠癌中VEGF及PCNA的阳性表达率分别为 4 5 .5 %及 84 .9%。结论 综合检测VEGF与PCNA ,对于直肠癌的诊断、治疗及预后有较明显的指导意义。

Objective To explore the detection of VEGF and PCNA in colorectal cancer to the significance of genesis,development and prognosis. Methods By means of immunohistochemistry technique(S\|P),to detect the expression of VEGF and PCNA in colorectal tissues, and combinated with histologic type and lymph node metastasis.Results The positive expression rate of VEGF and PCNA of normal colorectal tissue,colorectal adenoma and colorectal cancer are 15.4%, 16%,45.5%, 6.7%, 28% and 84.9% respectively.Conclusion Combinated detection of VEGF and PCNA can play an obviously direction role in diagnosis,treatment and prognosis of rectal cancer.